Cytoplasmic Transfer - Turkishdoc IVF Center

Cytoplasmic Transfer

Cytoplasmic transfer, also known as ooplasm transfer, is a new approach to in vitro fertilization (IVF), when IVF failure is associated with the deficient or damaged mitochondria. In this method, ooplasm, which is the cytoplasm of an egg, is taken from a younger donor to be transferred to achieve pregnancy. An ooplasm from a younger donor includes healthier cytoplasmic content; mitochondria, other organelles, and “unknown cytoplasmic factors”, which will eventually improve the quality of an egg.

Why is mitochondrial quality important to achieve pregnancy?

Energy generation, cell division, and cellular growth are all controlled by mitochondria, which is an organelle found in the cytoplasm of egg cells. According to a 2021 article, mitochondrial DNA replication ceases, and each cell division reduces the amount of mitochondria in each blastomere by 50% during fertilization. As a direct consequence of this, a relatively small number of mitochondria are found in each blastomere when the blastocyst is formed.

Mutations in mitochondrial DNA (mtDNA) occur 10 times more frequently than in nuclear DNA and, therefore, may cause mitochondrial dysfunction in blastocyst stage, especially after maternal age. As a result, mitochondrial dysfunction can induce recurrent implantation failures as well as high levels of embryo fragmentation, both of which are causes of poor embryo growth and, as a result, a failed IVF cycle. It can also cause poor embryo development.

Why is Cytoplasmic Transfer done?

Since mitochondrial dysfunction is commonly seen in women as they get older, those in their late 30s or early 40s who are trying to conceive through in vitro fertilization have a higher risk of having their attempts fail owing to this problem. Cytoplasmic transfer is performed during IVF treatment if any problem associated with mitochondrial dysfunction is suspected. This might be observed as a result of multiple IVF failures.

How is IVF with Cytoplasmic Transfer Performed?

In cytoplasmic transfer, the patient’s own eggs are used, but the procedure also requires an ooplasmic donor with relatively young age so that a healthy cytoplasm necessary for transplantation is acquired. Ooplasmic donor’s cytoplasm is transferred by direct injection or electrofusion. An egg that possesses cytoplasmic organelles from both their biological mother and the ooplasmic donor is then  fertilized with sperm and implanted in the uterus to achieve the pregnancy.

What are the risks of Cytoplasmic Transfer?

From a genetic point of view, combining nuclear DNA with a donor’s mitochondrial DNA (mtDNA) may pose some concerns. However, these concerns are a pretty advanced topic and still controversial due to the lack of solid evidence. It is best to discuss the eligibility of this operation for your case with your doctor.

Patient Stories

What do our patients say?

Turkishdoc is there for you from day one and stays by you at every step of your treatment.

Ahmed Johar
Ahmed Johar
2023-07-24
Trustindex verifies that the original source of the review is Google.
আমার বন্ধুর সাম্প্রতিক স্বাস্থ্য পর্যটন অভিজ্ঞতার সময় আপনি যে ব্যতিক্রমী পরিষেবা এবং যত্ন প্রদান করেছেন তার জন্য আপনাকে ধন্যবাদ। আপনার দক্ষতা এবং পেশাদারিত্ব অসামান্য ছিল, এবং আমরা আমাদের যাত্রা জুড়ে স্বাগত এবং ভাল যত্ন অনুভব করেছি। আপনার পরিষেবার ফলে আমরা যে ফলাফল অর্জন করেছি তার জন্য আমরা কৃতজ্ঞ, এবং আমি অন্যদের কাছে আপনার পরিষেবাগুলি সুপারিশ করার জন্য উন্মুখ।
Güzide Kürkçü
Güzide Kürkçü
2023-05-22
Trustindex verifies that the original source of the review is Google.
Kökhücre tedavisi için hizmet aldık. İlk baştan itibaren sorunsuz hizmet ve destek için çok teşekkür ederiz 🙏💫
Ceren Özgüven
Ceren Özgüven
2023-05-22
Trustindex verifies that the original source of the review is Google.
I am very satisfied with everything, thank you especially for the help of Yasmine
OnuR Uysal
OnuR Uysal
2023-05-18
Trustindex verifies that the original source of the review is Google.
grateful for your services.
Nergis Ekmen
Nergis Ekmen
2023-05-18
Trustindex verifies that the original source of the review is Google.
My aunt did IVF treatment through Turkishdoc, and we were really happy with the services they provided. We would like to thank all of the team for their great help.
Our Blog

Explore our blog for the latest insights on IVF in Turkey! Discover techniques, success stories and tips to achieve success.

The Possibility of Vaginal Delivery for IVF Mothers - Turkishdoc IVF
Celebrities Who Have Openly Embraced IVF
Ovarian Reserve Testing Can Provide Valuable Insights
Understanding AI in Embryo Development - Turkishdoc IVF
The Role of Folic Acid in Preparing for IVF Success - Turkishdoc IVF
Navigating the Path to Natural Pregnancy After IVF - Turkishdoc IVF
NEWS

Find the most up-to-date news from Turkishdoc on this page and keep
yourself updated for additional updates and announcements.

Turkishdoc IVF Center
Turkishdoc IVF Center
Turkishdoc IVF Center
Turkishdoc IVF Center
Turkishdoc IVF Center
Turkishdoc IVF Center
Turkishdoc IVF Center

Discover comprehensive answers to all your inquiries regarding IVF in Turkey.

Frequently Asked Questions

What is IVF?

IVF treatment (in vitro fertilization) was first successfully applied in England in 1978.

Factors that cause infertility (infertility) in women;

  • Ticking of the egg ducts (fallopian tubes)
  • Uterine (uterine) and congenital abnormalities
  • Benign uterine urlar (fibroids)
  • Intrauterine adhesions (uterine sineuses)

Factors that cause infertility (infertility) in men;

  • Low sperm count
  • Slowness in sperm movement
  • Disfigurement or inability to see sperm cells

According to statistics, more than 4 million children were born by IVF method all over the world.

IVF treatment has been a great gateway to hope for couples who cannot have children by natural means thanks to technology, improved laboratory facilities and research that have advanced in the last 30 years.

What are the factors affecting the success rate of IVF?

In vitro fertilization is one of the factors affecting the rate of success, especially:

  • The age of the patient
  • Type of infertility diagnosis
  • Duration of infertility
  • Hospital / doctor experience / expertise
  • Number of embryos transferred
  • Type of IVF performed: stimulated or natural cycle IVF

For women younger than 34, most will achieve pregnancy within 1 to 3 treatment cycles; indeed, many are successful on their first attempt.

Success rates for women over 35 tend to decrease as aging affects the quality of these women’s eggs.

For a detailed discussion about IVF success rates, couples should visit the website for the clinic where they are considering treatment. They should also discuss specific fertility possibilities with reproductive endocrinologists.

IVF pregnancy rates vary by clinic, so patients should carefully examine their chances of success in the treatment of specific clinical practice.

How is IVF performed?

At the beginning of the IVF process, the ovaries are stimulated with special drugs so that a large number of egg cells can be obtained from the woman.

This process varies from patient to patient.

Drugs are used for 15-20 days. After the ovaries become suitable with ultrasound and hormones with a blood test, egg collection is performed. Eggs are collected through the vaginal route with the help of ultrasound.

On the same day, sperm is taken from the man and a normal IVF or microinjection process is performed in the laboratory for the process of fertilization.

The fertilized egg, which becomes an Embryo, is transferred to the woman after two to five days.

What is infertility?

Infertility refers to the inability to conceive after having regular unprotected sex. Infertility refers to an individual’s biological incapacity to contribute to conception, or to a woman who is unable to carry her pregnancy to full maturity.

Infertility in many countries means a couple who cannot conceive after 12 months of regular sexual intercourse without using contraception.

Research shows that most cases of infertility are caused by more than half of women, with the rest due to sperm disorders or unidentified factors caused by men.

Most cases of apparent infertility are treatable. Infertility can have a single cause in one of the partners, or it can be the result of a combination of factors.

How soon can I get an appointment?

We provide pre-operative consultation to offer you the best treatment according to your needs. Fill out the form, and we’ll contact you to schedule a consultation appointment.

What language do they speak at Turkishdoc?

English, Turkish, Chinese, and Arabic are spoken by our staff. If another language is needed, we will arrange for a professional translation service.

For more information and support on IVF and infertility, consider reaching out to Turkishdoc and support organizations to access the guidance and resources you need on your journey.

For more information and support on IVF and infertility, consider reaching out to Turkishdoc and support organizations to access
the guidance and resources you need on your journey.

© 2023 Welcome to the website of Turkishdoc, meticulously crafted to navigate you through the exhilarating voyage of parenthood via IVF treatment.
G-PW85R5FXNT