Intracytoplasmic Sperm Injection (ICSI) - Turkishdoc IVF Center

Intracytoplasmic Sperm Injection (ICSI)

Intracytoplasmic Sperm Injection (ICSI), also known as microinjection, is a method where single, live sperm is directly injected into the egg. The approach was designed to aid couples with significant male factor infertility or women who experienced in vitro fertilization (IVF) cycle failure multiple times.

ICSI is a different approach to IVF procedure. During a traditional IVF procedure many live sperm cells are inserted in a petri dish with several eggs. A sperm reaching an egg fertilizes it as if it was in the uterus, meaning it happens naturally. However, there are several factors that may affect this to happen naturally, which might be the reason for infertility, or multiple IVF failure.

ICSI ensures that an egg is fertilized by directly injecting a single, live sperm to the egg. By being a more simple, straight-forward technique compared to traditional IVF, ICSI has replaced traditional IVF as the method of choice for treating infertility in developed economies.

When is ICSI Needed?

When male factor infertility is the concern or multiple IVF cycle failure experienced, you might be advised to apply for ICSI. There are several reasons explaining why an egg doesn’t get fertilized by sperm naturally. These include:

  • Thick egg membrane, which impedes sperm from entering.
  • Low sperm count, mobility and quality, which lowers the possibility of natural fertilization greatly. According to a 2021 study, low sperm cell quality affects approximately 50% of couples having infertility problems.
  • Problems regarding ejaculation, which might require surgical retrieval of sperm.
  • Fertilization after cryopreservation, where eggs and/or sperm previously frozen to be fertilized later.

How is ICSI performed?

Woman undergoes ovarian stimulation with fertility drugs and injections in order to develop multiple eggs. These eggs are subsequently retrieved through the vagina using vaginal ultrasonography and incubated in the embryology laboratory under strict circumstances. On the other hand, the sperm sample is obtained by ejaculation, surgical retrieval, or, if frozen, thawing.

Sample is centrifuged with a special medium and this step separates living sperm from the detritus and the majority of the dead sperm. The embryologist then selects and captures one live sperm and injects it with a glass needle into the egg.

What happens after ICSI?

Your doctor will monitor the fertilized egg for the following days and make sure that fertilization succeeds. A healthy fertilized egg should split into cells over the course of five to six days, developing into a blastocyst. Then, the blastocyst will be examined to determine if it is ready to be implanted.

Generally, a blastocyst will be ready in this time interval, 5th or 6th day after fertilization. Using ultrasound technology, a catheter will be inserted into your uterus for the egg to be planted. You can book a pregnancy test when your doctor advises.

What is the success rate of ICSI?

ICSI doesn’t have a great impact on IVF success rate. However, it presents a solution for the couples having treatment due to unexplained infertility. According to a recent study published in Frontiers, the use of ICSI to treat cases of unexplained infertility does not result in an increase in the number of live births, although it does produce a greater cancellation rate than traditional IVF.

What are the risks associated with ICSI?

Although it is mostly safe, there are several considerations regarding the ICSI procedure.

  • Injection with a needle may damage the eggs with a very low possibility.
  • Egg cannot get fertilized after the injection.
  • Embryos stop developing after fertilization or implantation.

Is one egg enough for ICSI?

An egg can be fertilized by only one sperm. However, for both traditional IVF and ICSI, 75% to 80% of the eggs are recovered. So, it isn’t logical to work with only one egg. This is the reason for ovary stimulation. A woman can produce one or two eggs each month. This number isn’t enough to secure a successful pregnancy, considering the success rate of IVF or ICSI, and the possibility that produced eggs are low quality. So ovaries are stimulated through fertility drugs and injections to produce more eggs. And all of the mature and healthy eggs are fertilized.

Successfully fertilized eggs (embryos) are then implanted to the uterus. The number of embryos to be implanted should be carefully determined. Using multiple embryos increases the chances of successful pregnancy, especially for women above 35. However, it can also cause multiple pregnancy, which may give rise to unwanted complications, and the need for multifetal pregnancy reduction.

You should consult your doctor about options available specifically for your case. If you’d like to learn more about ICSI, contact us. According to the ASRM, If a couple has in vitro fertilization with or without intracytoplasmic sperm injection (ICSI), their chances of having a singleton, or multiple pregnancy are the same once fertilization has taken place.

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Ahmed Johar
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আমার বন্ধুর সাম্প্রতিক স্বাস্থ্য পর্যটন অভিজ্ঞতার সময় আপনি যে ব্যতিক্রমী পরিষেবা এবং যত্ন প্রদান করেছেন তার জন্য আপনাকে ধন্যবাদ। আপনার দক্ষতা এবং পেশাদারিত্ব অসামান্য ছিল, এবং আমরা আমাদের যাত্রা জুড়ে স্বাগত এবং ভাল যত্ন অনুভব করেছি। আপনার পরিষেবার ফলে আমরা যে ফলাফল অর্জন করেছি তার জন্য আমরা কৃতজ্ঞ, এবং আমি অন্যদের কাছে আপনার পরিষেবাগুলি সুপারিশ করার জন্য উন্মুখ।
Güzide Kürkçü
Güzide Kürkçü
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Ceren Özgüven
Ceren Özgüven
I am very satisfied with everything, thank you especially for the help of Yasmine
OnuR Uysal
OnuR Uysal
grateful for your services.
Nergis Ekmen
Nergis Ekmen
My aunt did IVF treatment through Turkishdoc, and we were really happy with the services they provided. We would like to thank all of the team for their great help.
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Discover comprehensive answers to all your inquiries regarding IVF in Turkey.

Frequently Asked Questions

What is IVF?

IVF treatment (in vitro fertilization) was first successfully applied in England in 1978.

Factors that cause infertility (infertility) in women;

  • Ticking of the egg ducts (fallopian tubes)
  • Uterine (uterine) and congenital abnormalities
  • Benign uterine urlar (fibroids)
  • Intrauterine adhesions (uterine sineuses)

Factors that cause infertility (infertility) in men;

  • Low sperm count
  • Slowness in sperm movement
  • Disfigurement or inability to see sperm cells

According to statistics, more than 4 million children were born by IVF method all over the world.

IVF treatment has been a great gateway to hope for couples who cannot have children by natural means thanks to technology, improved laboratory facilities and research that have advanced in the last 30 years.

What are the factors affecting the success rate of IVF?

In vitro fertilization is one of the factors affecting the rate of success, especially:

  • The age of the patient
  • Type of infertility diagnosis
  • Duration of infertility
  • Hospital / doctor experience / expertise
  • Number of embryos transferred
  • Type of IVF performed: stimulated or natural cycle IVF

For women younger than 34, most will achieve pregnancy within 1 to 3 treatment cycles; indeed, many are successful on their first attempt.

Success rates for women over 35 tend to decrease as aging affects the quality of these women’s eggs.

For a detailed discussion about IVF success rates, couples should visit the website for the clinic where they are considering treatment. They should also discuss specific fertility possibilities with reproductive endocrinologists.

IVF pregnancy rates vary by clinic, so patients should carefully examine their chances of success in the treatment of specific clinical practice.

How is IVF performed?

At the beginning of the IVF process, the ovaries are stimulated with special drugs so that a large number of egg cells can be obtained from the woman.

This process varies from patient to patient.

Drugs are used for 15-20 days. After the ovaries become suitable with ultrasound and hormones with a blood test, egg collection is performed. Eggs are collected through the vaginal route with the help of ultrasound.

On the same day, sperm is taken from the man and a normal IVF or microinjection process is performed in the laboratory for the process of fertilization.

The fertilized egg, which becomes an Embryo, is transferred to the woman after two to five days.

What is infertility?

Infertility refers to the inability to conceive after having regular unprotected sex. Infertility refers to an individual’s biological incapacity to contribute to conception, or to a woman who is unable to carry her pregnancy to full maturity.

Infertility in many countries means a couple who cannot conceive after 12 months of regular sexual intercourse without using contraception.

Research shows that most cases of infertility are caused by more than half of women, with the rest due to sperm disorders or unidentified factors caused by men.

Most cases of apparent infertility are treatable. Infertility can have a single cause in one of the partners, or it can be the result of a combination of factors.

How soon can I get an appointment?

We provide pre-operative consultation to offer you the best treatment according to your needs. Fill out the form, and we’ll contact you to schedule a consultation appointment.

What language do they speak at Turkishdoc?

English, Turkish, Chinese, and Arabic are spoken by our staff. If another language is needed, we will arrange for a professional translation service.

For more information and support on IVF and infertility, consider reaching out to Turkishdoc and support organizations to access the guidance and resources you need on your journey.

For more information and support on IVF and infertility, consider reaching out to Turkishdoc and support organizations to access
the guidance and resources you need on your journey.

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